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Human axial progenitors generate trunk neural crest cells in vitro
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Specifically, trunk NC production has been shown to be controlled by transcription factors which also regulate cell fate decisions in axial progenitors such as CDX proteins Sanchez-Ferras et al. The close relationship between bipotent axial and posterior NC progenitors is further supported by fate mapping experiments involving the grafting of a portion of E8. We review the environmental and behavioral carcinogens currently known to be responsible for a large fraction of U. We then review prospects for preventing cancer by drugs or other mechanism-based interventions. We examine the importance of identifying high-risk individuals who can most benefit from prevention or early detection.
We then briefly turn to early detection itself and discuss the significant problems associated with population screening. We review successful screening methods in use in the U. We conclude with the prospect for novel screening methods based on advances in the genetics and molecular biology of cancer. In the final section, we consider how much cancer is biologically intrinsic versus how much is caused by exposure to environmental, occupational, and behavioral carcinogens and the role of aging in cancer and the possibility of preventing or delaying cancer by delaying aging itself. The prevention of cancer Surprising discoveries from cancer epidemiology In theory, the majority of cancers may be preventable It has been known for nearly yr that at least some cancers are caused by environmental, occupational, or behavioral exposures, scrotal cancer in chimney sweeps being a famous early example Pott ; excerpted in National Cancer Institute However, what fraction of all cancers is caused by such exposures and what fraction is caused solely by intrinsic biological processes?
Epidemiologists provided a first answer half a century ago using statistical methods and data from cancer registries Kolonel et al.
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